The HCNS involves more than 400 scientists and doctoral students, 27 institutes and clinical departments mainly located at UKE and UHH. The scientific scope is broad, including molecular, animal, cognitive, computational and clinical neuroscience. It comprises several CRCs (CRC 936 – Multi-Site Communication in the Brain, TRR 169 Crossmodal Learning: Adaptivity, Prediction and Interaction), TRR 58 Fear Anxiety and Anxiety Disorders, and TRR 289 Treatment Expectation research groups (e.g. FOR 2419 – Plasticity versus Stability – Molecular Mechanisms of Synaptic Strength), focus programs (Priority program 1665 – Resolving and Manipulating Neuronal Networks in the Mammalian Brain – From Correlative to causal analyses) and further DFG-, BMBF-, and EU-funded projects, such as IMAGEN. One focus of the HCNS is brain plasticity and the development of interventions to target circumscribed functions relevant to mental illness (e.g., impulsivity). National and international partners include, the National Institutes of Health (NIH), Stanford University, University College London (UCL), and Harvard Medical School. The majority of MH-TRN PIs in the field of basic science are involved in the HCNS.